The Vaccine Equity Partner Engagement (VEPE) Project supports equitable access to COVID-19 vaccines and vaccines. Through the initiative, the New York City Department of Health and Mental Hygiene (DOHMH), in partnership with the Fund for Public Health in New York, Inc. (FPHNYC), we lead outreach, engagement, and navigation for communities disproportionately impacted by COVID-19, racism, and disinvestment. Tailored strategies led by credible messengers are imperative to increase reach and build vaccine literacy, confidence, and trust with priority communities.